Across TCGA pan-cancer cohorts, IGKV1OR2-2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR2-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-2 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and STAD are the cancer types where IGKV1OR2-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.568	<.001	9	view →
BRCA	All	III,IV	−0.198	<.001	6	view →
STAD	Male	All	−0.451	.022	4	view →
LUAD	All	All	+0.188	.002	3	view →
READ	Female	All	−0.360	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGKV1OR2-2 RNA expression & survival · all IGKV1OR2-2 data types