IGKV1OR2-118

Across TCGA pan-cancer cohorts, IGKV1OR2-118 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-118 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-118 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR2-118 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where IGKV1OR2-118 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.497	0.241	<.001	105	view →
SKCM	DFS	Median	III,IV	0.675	0.405	.005	52	view →
ACC	DFS	Tertile	All	0.137	0.673	.003	48	view →
MESO	OS	Quartile	III,IV	0.786	0.491	.002	38	view →
STAD	DFS	Quartile	All	0.540	0.787	<.001	32	view →
LIHC	OS	Tertile	III,IV	0.846	0.598	.024	27	view →
TGCT	DFS	Quartile	All	0.918	0.730	.024	18	view →
LUAD	DFS	Quartile	II,III,IV	0.747	0.429	.009	18	view →
ESCA	DFS	Median	II,III,IV	0.389	0.221	.019	14	view →
COAD	DFS	Tertile	All	0.882	0.746	.026	11	view →
PAAD	OS	Quartile	II,III,IV	0.727	0.528	.010	10	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV1OR2-118–HNSC (DFS)

Open the HNSC breakdown →