IGKV1OR2-118

Across TCGA pan-cancer cohorts, IGKV1OR2-118 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-118’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR2-118 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-118 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, STAD, and LUAD are the cancer types where IGKV1OR2-118 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-118 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	−1.535	<.001	10	view →
STAD	All	All	−0.864	.025	6	view →
LUAD	Female	All	+0.729	<.001	6	view →
BRCA	Female	All	−0.155	.003	4	view →
KIRC	All	All	+0.096	.007	3	view →
READ	All	All	−0.687	.002	2	view →
PAAD	Female	All	−0.270	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGKV1OR2-118–COAD

Open the COAD breakdown →