IGKV1OR2-108

Across TCGA pan-cancer cohorts, IGKV1OR2-108 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-108 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-108 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR2-108 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1OR2-108 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.776	0.616	<.001	116	view →
SKCM	OS	Median	All	0.861	0.689	<.001	91	view →
BRCA	OS	Median	All	0.977	0.947	<.001	88	view →
LGG	OS	Tertile	All	0.701	0.839	<.001	39	view →
UVM	DFS	Tertile	All	0.451	0.796	.006	36	view →
GBM	OS	Tertile	All	0.332	0.463	.003	33	view →
CESC	DFS	Quartile	All	0.855	0.662	.003	26	view →
KIRP	DFS	Quartile	All	0.565	0.861	.002	22	view →
TGCT	DFS	Quartile	All	0.837	0.582	.005	18	view →
COAD	DFS	Median	All	0.579	0.457	.006	13	view →
READ	DFS	Median	IV	0.797	0.420	.024	12	view →
STAD	DFS	Median	IV	0.670	0.171	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

IGKV1OR2-108–HNSC (DFS)

Open the HNSC breakdown →