IGKV1OR2-108

Across TCGA pan-cancer cohorts, IGKV1OR2-108 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-108’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR2-108 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-108 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV1OR2-108 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-108 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.384	<.001	10	view →
LUAD	Female	All	+2.267	<.001	7	view →
BRCA	Female	II,III,IV	−1.320	<.001	6	view →
KIRC	All	All	+0.826	<.001	4	view →
ESCA	All	II,III,IV	+3.374	.035	3	view →
READ	All	All	−2.692	.003	3	view →
STAD	All	IV	−4.130	.034	1	view →
HNSC	All	III,IV	+1.133	.018	1	view →
KICH	All	All	−0.803	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV1OR2-108–COAD

Open the COAD breakdown →