IGKV1OR2-108

Across TCGA pan-cancer cohorts, IGKV1OR2-108 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV1OR2-108 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1OR2-108 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1OR2-108 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where IGKV1OR2-108 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.460	1.000	.013	14	view →
CCRCC	DFS	Tertile	III,IV	0.778	0.278	.001	13	view →
LSCC	DFS	Tertile	III,IV	1.000	0.525	.021	4	view →
HNSC	DFS	Tertile	IV	0.851	0.512	.031	3	view →
GBM	DFS	Median	All	0.658	0.866	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV1OR2-108–LUAD (DFS)

Open the LUAD breakdown →