IGKV1OR2-108

Across TCGA pan-cancer cohorts, IGKV1OR2-108 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-108’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGKV1OR2-108 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-108 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where IGKV1OR2-108 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-108 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.036	<.001	8	view →
LUAD	Male	II,III,IV	−0.481	<.001	5	view →
PDAC	Female	All	+0.960	<.001	4	view →
CCRCC	All	All	+0.431	<.001	4	view →
LSCC	All	All	−0.300	.012	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGKV1OR2-108–HNSC

Open the HNSC breakdown →