IGKV1OR10-1

Across TCGA pan-cancer cohorts, IGKV1OR10-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV1OR10-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR10-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR10-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where IGKV1OR10-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.799	0.640	<.001	128	view →
UVM	OS	Tertile	II,III,IV	0.189	0.729	.001	81	view →
SKCM	OS	Quartile	All	0.461	0.296	.001	72	view →
KICH	DFS	Tertile	All	0.432	0.914	.001	63	view →
BRCA	OS	Quartile	All	0.990	0.954	<.001	47	view →
DLBC	DFS	Median	II,III,IV	1.000	0.189	.003	33	view →
CHOL	DFS	Tertile	All	0.773	0.232	.002	24	view →
LUAD	DFS	Quartile	II,III,IV	0.810	0.486	.005	23	view →
KIRP	DFS	Quartile	All	0.547	0.831	.011	23	view →
STAD	DFS	Tertile	IV	0.670	0.171	.017	16	view →
ACC	OS	Tertile	II,III,IV	0.140	0.586	.007	9	view →
PAAD	OS	Median	II,III,IV	0.642	0.528	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV1OR10-1–HNSC (DFS)

Open the HNSC breakdown →