IGKV1OR10-1

Across TCGA pan-cancer cohorts, IGKV1OR10-1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR10-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR10-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR10-1 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV1OR10-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR10-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.610	<.001	9	view →
LUAD	Female	All	+0.851	<.001	7	view →
BRCA	Female	II,III,IV	−0.260	.003	6	view →
KIRC	All	All	+0.162	.006	6	view →
READ	Female	All	−1.212	.002	2	view →
LUSC	All	All	+0.357	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGKV1OR10-1–COAD

Open the COAD breakdown →