IGKV1OR-2

Across TCGA pan-cancer cohorts, IGKV1OR-2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGKV1OR-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR-2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1OR-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and KIRC are the cancer types where IGKV1OR-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.858	0.713	<.001	95	view →
LUAD	OS	Quartile	II,III,IV	0.942	0.667	<.001	59	view →
KIRC	DFS	Tertile	IV	0.191	0.414	.007	42	view →
BRCA	DFS	Tertile	All	0.591	0.487	.003	39	view →
SKCM	DFS	Quartile	All	0.781	0.594	.004	27	view →
COAD	OS	Quartile	II,III,IV	0.941	0.567	.003	24	view →
ESCA	OS	Tertile	II,III,IV	0.648	0.438	.014	19	view →
LAML	DFS	Tertile	All	0.202	0.469	.026	16	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.569	.008	15	view →
KIRP	DFS	Tertile	IV	0.035	0.525	.023	15	view →
TGCT	DFS	Tertile	All	0.941	0.753	.018	12	view →
BLCA	OS	Tertile	III,IV	0.735	0.622	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGKV1OR-2–HNSC (OS)

Open the HNSC breakdown →