IGKV1OR-2

Across TCGA pan-cancer cohorts, IGKV1OR-2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR-2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR-2 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, KIRP, and LUAD are the cancer types where IGKV1OR-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.471	<.001	9	view →
KIRP	Male	II,III,IV	+0.359	.003	8	view →
LUAD	All	II,III,IV	+0.415	<.001	7	view →
BRCA	Female	II,III,IV	−0.149	<.001	6	view →
STAD	All	IV	−2.433	.007	5	view →
READ	Female	All	−0.681	<.001	2	view →
KIRC	Female	III,IV	−0.055	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGKV1OR-2–COAD

Open the COAD breakdown →