IGKV1D-43

Across TCGA pan-cancer cohorts, IGKV1D-43 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGKV1D-43 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGKV1D-43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1D-43 expression acts as an unfavorable survival marker.

LUSC, OV, and SKCM are the cancer types where IGKV1D-43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.150	0.724	.005	15	view →
OV	DFS	Median	II,III,IV	0.204	0.541	.017	12	view →
SKCM	OS	Median	All	0.257	0.781	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IGKV1D-43–LUSC (OS)

Open the LUSC breakdown →