IGKV1D-39

Across TCGA pan-cancer cohorts, IGKV1D-39 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV1D-39 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-39 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-39 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1D-39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.673	0.532	<.001	144	view →
SKCM	DFS	Median	All	0.680	0.554	<.001	108	view →
BRCA	DFS	Median	All	0.967	0.931	<.001	96	view →
KIRP	DFS	Tertile	All	0.529	0.880	.001	31	view →
UVM	OS	Tertile	All	0.498	0.851	.012	27	view →
ACC	DFS	Tertile	II,III,IV	0.137	0.590	.041	27	view →
PAAD	OS	Quartile	II,III,IV	0.711	0.472	.002	23	view →
BLCA	DFS	Quartile	All	0.551	0.195	.006	21	view →
CHOL	DFS	Quartile	All	0.794	0.294	.013	18	view →
LUAD	OS	Quartile	II,III,IV	0.746	0.490	.017	17	view →
KIRC	DFS	Quartile	All	0.695	0.854	.011	16	view →
COAD	DFS	Median	All	0.755	0.629	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV1D-39–HNSC (DFS)

Open the HNSC breakdown →