IGKV1D-39

Across TCGA pan-cancer cohorts, IGKV1D-39 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGKV1D-39’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1D-39 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1D-39 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV1D-39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1D-39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.662	<.001	10	view →
LUAD	Female	All	+1.732	<.001	8	view →
BRCA	Female	All	−0.338	.037	4	view →
READ	All	All	−2.322	.001	3	view →
HNSC	Female	III,IV	+0.850	.033	2	view →
UCEC	All	III,IV	−0.542	.044	2	view →
KIRC	All	All	+0.373	.006	2	view →
CHOL	All	II,III,IV	−0.334	.046	2	view →
STAD	All	IV	−4.073	.033	1	view →
LIHC	Male	All	−0.266	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGKV1D-39–COAD

Open the COAD breakdown →