IGKV1D-32

Across TCGA pan-cancer cohorts, IGKV1D-32 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGKV1D-32 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGKV1D-32 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1D-32 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

UVM, HNSC, and KICH are the cancer types where IGKV1D-32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
HNSC	DFS	Tertile	All	0.839	0.681	.003	90	view →
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
MESO	DFS	Tertile	III,IV	0.099	0.495	.001	36	view →
GBM	DFS	Tertile	All	0.048	0.257	.001	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
SKCM	DFS	Tertile	III,IV	0.689	0.475	.018	15	view →
THYM	DFS	Tertile	All	0.174	0.813	.029	9	view →
THCA	DFS	Tertile	II,III,IV	1.000	0.701	.042	6	view →
ESCA	OS	Tertile	III,IV	0.752	0.358	.033	6	view →
STAD	DFS	Quartile	IV	0.083	0.378	.002	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGKV1D-32–UVM (OS)

Open the UVM breakdown →