IGKV1D-22

Across TCGA patient cohorts, IGKV1D-22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,502 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV1D-22-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and Complement activation, classical pathway. Each is linked with IGKV1D-22 in more than 20 cancer types. Because this analysis shows association rather than direction, both IGKV1D-22-to-partner and partner-to-IGKV1D-22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV1D-22-low versus IGKV1D-22-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-22→partner) and Y-score (partner→IGKV1D-22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.104	+0.137	<.001	<.001	3	21
ESCA	Immunoglobulin production →	+0.082	+0.080	<.001	<.001	3	20
THCA	Complement activation, classical pathway →	+0.170	+0.120	<.001	<.001	3	20
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.144	+0.120	<.001	<.001	3	19
ESCA	B cell receptor signaling pathway →	+0.098	+0.078	<.001	<.001	3	19
THCA	Complement activation →	+0.140	+0.118	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,502 associations by consensus.

B cell mediated immunity by IGKV1D-22 expression — THCA

Explore this box plot interactively →