IGKV1D-22

Across TCGA pan-cancer cohorts, IGKV1D-22 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGKV1D-22 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGKV1D-22 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-22 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

ESCA, HNSC, and LAML are the cancer types where IGKV1D-22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	II,III,IV	0.534	0.246	.003	105	view →
HNSC	OS	Tertile	III,IV	0.912	0.712	.004	96	view →
LAML	DFS	Median	All	0.676	0.457	.001	24	view →
CESC	DFS	Tertile	IV	0.744	0.167	.025	18	view →
LIHC	OS	Tertile	III,IV	0.226	0.659	.003	18	view →
STAD	DFS	Tertile	All	0.521	0.677	.007	14	view →
BLCA	OS	Tertile	IV	0.905	0.554	.010	9	view →
PCPG	DFS	Tertile	All	0.067	0.857	<.001	9	view →
READ	OS	Tertile	III,IV	0.601	0.766	.047	9	view →
LUSC	OS	Quartile	All	0.548	0.768	.006	7	view →
UCS	DFS	Tertile	All	1.000	0.224	.049	6	view →
GBM	DFS	Tertile	All	1.000	0.192	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGKV1D-22–ESCA (DFS)

Open the ESCA breakdown →