IGKV1D-17

Across TCGA patient cohorts, IGKV1D-17 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,929 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-17-associated GO terms across cancer lineages are Antibacterial humoral response, Humoral immune response mediated by circulating immunoglobulin, and B cell receptor signaling pathway. Each is linked with IGKV1D-17 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGKV1D-17-to-partner and partner-to-IGKV1D-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antibacterial humoral response grouped by IGKV1D-17-low versus IGKV1D-17-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-17→partner) and Y-score (partner→IGKV1D-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Antibacterial humoral response →	+0.158	+2.074	<.001	.001	3	30
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.149	+1.594	<.001	<.001	3	30
CHOL	B cell receptor signaling pathway →	+0.127	+2.320	<.001	<.001	3	30
THCA	Complement activation, classical pathway →	+0.182	+1.638	<.001	<.001	3	30
THCA	Antimicrobial humoral response →	+0.102	+1.639	<.001	<.001	3	29
THCA	Complement activation →	+0.143	+1.593	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,929 associations by consensus.

Antibacterial humoral response by IGKV1D-17 expression — CHOL

Explore this box plot interactively →