IGKV1D-17

Across TCGA patient cohorts, IGKV1D-17 protein abundance is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1D-17-associated genes across cancer lineages are KNTC1, MIR1302-4, and KLC3. Each is linked with IGKV1D-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-17-to-partner and partner-to-IGKV1D-17 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1D-17 versus KNTC1 in LUAD, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-17→partner) and Y-score (partner→IGKV1D-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KNTC1 →	+0.583	+0.661	.007	.005	3	1
LUAD	MIR1302-4 →	+0.875	+1.685	.007	.009	3	1
LUAD	KLC3 →	-1.660	-0.826	<.001	.002	2	1
LUAD	ZDHHC8P1 →	-1.693	-0.826	.008	.002	2	1
LUAD	CYP2J2 →	-1.983	-0.713	.003	.009	2	1
LUAD	RPS8 →	-0.689	-0.826	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

IGKV1D-17 vs KNTC1 — LUAD

Explore this scatter interactively →