IGKV1D-17

Across TCGA patient cohorts, IGKV1D-17 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1D-17-associated genes across cancer lineages are EGFR_pY1068, Ku80, and FOXO3a. Each is linked with IGKV1D-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-17-to-partner and partner-to-IGKV1D-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IGKV1D-17-low versus IGKV1D-17-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-17→partner) and Y-score (partner→IGKV1D-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EGFR_pY1068 →	+0.511	+2.816	.038	.036	3	1
LUSC	Ku80 →	+0.380	+2.834	.043	.035	3	1
UCEC	FOXO3a →	-0.121	-2.986	.039	.037	3	1
LUSC	Chk2 →	+0.318	+2.816	.033	.036	2	1
UCEC	MSH2 →	-0.382	-3.000	.004	.037	2	1
UCEC	MIG-6 →	+0.116	+3.013	.044	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by IGKV1D-17 expression — LUSC

Explore this box plot interactively →