IGKV1D-16

Across TCGA patient cohorts, IGKV1D-16 protein abundance is significantly associated with the RNA expression of many other genes, with 7,334 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1D-16-associated genes across cancer lineages are SAMSN1, SRGN, and AP1M2. Each is linked with IGKV1D-16 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGKV1D-16-to-partner and partner-to-IGKV1D-16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1D-16 versus SAMSN1 in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-16→partner) and Y-score (partner→IGKV1D-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAMSN1 →	+1.232	+1.026	<.001	<.001	3	5
COAD	SRGN →	+1.432	+0.361	<.001	.004	3	4
LUAD	AP1M2 →	-0.764	-0.490	<.001	<.001	3	4
LSCC	TMEM97 →	-0.863	-0.546	<.001	<.001	3	3
LSCC	YWHAQ →	-0.473	-0.711	.004	.003	3	3
COAD	CYSLTR1 →	+1.140	+0.376	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,334 associations by consensus.

IGKV1D-16 vs SAMSN1 — GBM

Explore this scatter interactively →