IGKV1D-13

Across TCGA pan-cancer cohorts, IGKV1D-13 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV1D-13 data layer compared with 18 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGKV1D-13 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1D-13 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where IGKV1D-13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.630	0.954	.005	31	view →
HNSC	DFS	Tertile	All	0.528	0.760	.014	9	view →
LUAD	OS	Median	III,IV	0.231	0.620	.022	3	view →
UCEC	DFS	Quartile	All	0.743	0.931	.047	2	view →
CCRCC	OS	Quartile	All	0.962	0.813	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV1D-13–LSCC (OS)

Open the LSCC breakdown →