IGKV1-9

Across TCGA pan-cancer cohorts, IGKV1-9 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV1-9 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IGKV1-9 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1-9 expression acts as an unfavorable survival marker.

READ and PRAD are the cancer types where IGKV1-9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
PRAD	DFS	Median	All	0.152	0.774	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV1-9–READ (DFS)

Open the READ breakdown →