IGKV1-8

Across TCGA patient cohorts, IGKV1-8 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1-8-associated genes across cancer lineages are SDR42E1P4, LINC00905, and RNU6-493P. Each is linked with IGKV1-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-8-to-partner and partner-to-IGKV1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDR42E1P4 grouped by IGKV1-8-low versus IGKV1-8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-8→partner) and Y-score (partner→IGKV1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDR42E1P4 →	+0.199	+8.066	<.001	.007	3	1
LUAD	LINC00905 →	+0.031	+5.217	<.001	.007	3	1
LUAD	RNU6-493P →	+0.464	+6.739	<.001	<.001	3	1
LUAD	PDE4DIPP8 →	+0.086	+5.044	<.001	.009	3	1
LUAD	RNU6-1178P →	+1.309	+5.343	<.001	.006	3	1
LUAD	DPPA5P2 →	+0.226	+5.099	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SDR42E1P4 by IGKV1-8 expression — UCEC

Explore this box plot interactively →