IGKV1-8

Across TCGA pan-cancer cohorts, IGKV1-8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGKV1-8 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGKV1-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.777	0.641	<.001	143	view →
SKCM	OS	Median	II,III,IV	0.931	0.745	<.001	101	view →
UCEC	OS	Tertile	III,IV	0.759	0.343	<.001	62	view →
LUAD	OS	Quartile	All	0.786	0.656	.004	54	view →
SARC	OS	Median	All	0.609	0.403	<.001	41	view →
UVM	OS	Tertile	II,III,IV	0.371	0.699	.018	40	view →
BRCA	OS	Median	All	0.973	0.951	.003	26	view →
LGG	OS	Tertile	All	0.406	0.537	.009	24	view →
LIHC	DFS	Quartile	III,IV	0.591	0.164	.004	23	view →
GBM	OS	Tertile	All	0.241	0.479	.002	18	view →
KIRC	DFS	Tertile	All	0.542	0.785	.008	16	view →
ACC	DFS	Tertile	All	0.781	0.500	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGKV1-8–HNSC (DFS)

Open the HNSC breakdown →