IGKV1-6

Across TCGA pan-cancer cohorts, IGKV1-6 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV1-6 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1-6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-6 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD are the cancer types where IGKV1-6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.875	0.399	.040	5	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGKV1-6–LUAD (DFS)

Open the LUAD breakdown →