IGKV1-5

Across TCGA pan-cancer cohorts, IGKV1-5 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated IGKV1-5 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGKV1-5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1-5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

COAD, HNSC, and UCEC are the cancer types where IGKV1-5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.914	1.000	.027	12	view →
HNSC	DFS	Tertile	All	0.894	1.000	.003	11	view →
UCEC	OS	Quartile	All	0.862	1.000	.014	6	view →
CCRCC	OS	Median	All	0.953	0.831	.012	5	view →
GBM	OS	Quartile	All	0.279	0.575	.014	5	view →
LSCC	DFS	Median	All	0.937	0.567	.006	3	view →
LUAD	OS	Quartile	III,IV	0.721	1.000	.031	2	view →
PDAC	OS	Tertile	II,III,IV	0.757	0.947	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV1-5–COAD (DFS)

Open the COAD breakdown →