IGKV1-5

Across TCGA pan-cancer cohorts, IGKV1-5 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGKV1-5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGKV1-5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGKV1-5 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where IGKV1-5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.812	<.001	8	view →
COAD	All	II,III,IV	−0.545	<.001	8	view →
LUAD	Female	All	−0.535	<.001	8	view →
LSCC	Male	All	−0.316	<.001	5	view →
CCRCC	All	All	+0.377	<.001	4	view →
PDAC	All	All	+0.578	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGKV1-5–HNSC

Open the HNSC breakdown →