IGKV1-35

Across TCGA pan-cancer cohorts, IGKV1-35 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGKV1-35 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGKV1-35 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1-35 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

SKCM, GBM, and UCEC are the cancer types where IGKV1-35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.498	0.318	.006	42	view →
GBM	OS	Tertile	All	0.076	0.419	<.001	36	view →
UCEC	OS	Tertile	IV	0.308	0.748	.009	30	view →
STAD	DFS	Quartile	III,IV	0.232	0.402	.017	20	view →
THYM	OS	Tertile	II,III,IV	0.585	0.903	.030	18	view →
LUAD	OS	Quartile	II,III,IV	0.094	0.336	.012	16	view →
ESCA	DFS	Tertile	II,III,IV	0.447	0.261	.029	11	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
PAAD	DFS	Tertile	II,III,IV	0.560	0.389	.039	6	view →
KIRC	OS	Tertile	All	0.708	0.811	.045	6	view →
DLBC	OS	Tertile	All	0.656	0.937	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGKV1-35–SKCM (OS)

Open the SKCM breakdown →