IGKV1-35

Across TCGA pan-cancer cohorts, IGKV1-35 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV1-35’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-35 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-35 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, STAD, and LUAD are the cancer types where IGKV1-35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.448	<.001	7	view →
STAD	All	All	−0.462	.003	6	view →
LUAD	All	All	+0.207	<.001	5	view →
HNSC	All	IV	+0.085	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGKV1-35–COAD

Open the COAD breakdown →