IGKV1-27

Across TCGA patient cohorts, IGKV1-27 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1-27-associated genes across cancer lineages are RNU6-669P, ATIC, and RTF2. Each is linked with IGKV1-27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-27-to-partner and partner-to-IGKV1-27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-669P grouped by IGKV1-27-low versus IGKV1-27-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-27→partner) and Y-score (partner→IGKV1-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-669P →	+0.537	+5.303	<.001	.006	3	2
SKCM	ATIC →	+0.383	+2.534	.003	.001	3	2
SKCM	RTF2 →	+0.392	+3.632	<.001	.001	3	2
SKCM	EIF3C →	+0.379	+2.508	.004	.001	3	2
SKCM	RNU6-192P →	+0.091	+3.716	<.001	.001	3	2
HNSC	NANOGNBP1 →	+0.114	+5.655	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

RNU6-669P by IGKV1-27 expression — HNSC

Explore this box plot interactively →