IGKV1-27

Across TCGA pan-cancer cohorts, IGKV1-27 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV1-27 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-27 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-27 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV1-27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.756	0.634	<.001	147	view →
BRCA	DFS	Median	All	0.972	0.925	<.001	99	view →
SKCM	OS	Median	All	0.936	0.796	<.001	74	view →
UCEC	DFS	Tertile	III,IV	0.674	0.391	.003	38	view →
KIRP	OS	Tertile	All	0.531	0.771	.007	31	view →
UVM	OS	Tertile	III,IV	0.363	0.781	.027	28	view →
STAD	DFS	Quartile	All	0.537	0.759	.004	20	view →
LIHC	DFS	Median	III,IV	0.563	0.214	.001	19	view →
CHOL	DFS	Tertile	All	0.717	0.211	.001	18	view →
CESC	OS	Median	All	0.872	0.718	<.001	18	view →
SARC	OS	Tertile	All	0.656	0.457	.005	8	view →
READ	DFS	Tertile	IV	0.798	0.452	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV1-27–HNSC (DFS)

Open the HNSC breakdown →