IGKV1-27

Across TCGA patient cohorts, IGKV1-27 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1-27-associated genes across cancer lineages are Neurons, aDC, and Megakaryocytes. Each is linked with IGKV1-27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-27-to-partner and partner-to-IGKV1-27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neurons grouped by IGKV1-27-low versus IGKV1-27-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-27→partner) and Y-score (partner→IGKV1-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Neurons →	+0.015	+2.816	.042	.036	3	2
SKCM	aDC →	-0.105	-2.690	.005	.006	3	1
SKCM	Megakaryocytes →	+0.025	+1.718	.006	.032	3	1
LUSC	CD8+ naive T-cells →	-0.031	-3.000	.021	.037	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Neurons by IGKV1-27 expression — LUSC

Explore this box plot interactively →