IGKV1-22

Across TCGA pan-cancer cohorts, IGKV1-22 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGKV1-22 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGKV1-22 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1-22 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

KICH, PAAD, and CHOL are the cancer types where IGKV1-22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.369	0.922	<.001	108	view →
PAAD	OS	Tertile	II,III,IV	0.831	0.553	.010	42	view →
CHOL	DFS	Tertile	All	0.045	0.497	.029	36	view →
GBM	OS	Tertile	All	0.161	0.421	.005	18	view →
LGG	OS	Tertile	All	0.358	0.834	<.001	18	view →
LUSC	OS	Tertile	III,IV	0.691	0.228	.007	18	view →
LUAD	DFS	Quartile	All	0.782	0.639	.013	13	view →
STAD	OS	Median	IV	0.642	0.203	.006	9	view →
BLCA	OS	Tertile	IV	1.000	0.574	.037	6	view →
SKCM	DFS	Tertile	II,III,IV	0.949	0.674	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGKV1-22–KICH (DFS)

Open the KICH breakdown →