IGKV1-22

Across TCGA pan-cancer cohorts, IGKV1-22 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGKV1-22’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGKV1-22 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-22 is over-expressed in tumor, although a few such as STAD and COAD show the opposite, repressed pattern.

STAD, LUAD, and COAD are the cancer types where IGKV1-22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-22 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	IV	−0.760	.016	3	view →
LUAD	All	All	+0.070	.001	2	view →
COAD	All	All	−0.112	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGKV1-22–STAD

Open the STAD breakdown →