IGKV1-17

Across TCGA pan-cancer cohorts, IGKV1-17 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV1-17 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1-17 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1-17 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD and HNSC are the cancer types where IGKV1-17 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.840	1.000	.022	10	view →
HNSC	OS	Quartile	All	0.886	0.579	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV1-17–LUAD (OS)

Open the LUAD breakdown →