IGKV1-16

Across TCGA pan-cancer cohorts, IGKV1-16 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV1-16 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IGKV1-16 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1-16 expression acts as an unfavorable survival marker.

LIHC are the cancer types where IGKV1-16 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.098	0.777	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGKV1-16–LIHC (OS)

Open the LIHC breakdown →