IGKV1-16

Across TCGA pan-cancer cohorts, IGKV1-16 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV1-16 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGKV1-16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1-16 expression acts as an unfavorable survival marker.

UCEC, CCRCC, and HNSC are the cancer types where IGKV1-16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.759	1.000	<.001	24	view →
CCRCC	DFS	Quartile	II,III,IV	0.198	0.887	.024	9	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	6	view →
LUAD	DFS	Tertile	All	0.463	0.775	.015	2	view →
GBM	OS	Median	All	0.278	0.441	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV1-16–UCEC (DFS)

Open the UCEC breakdown →