IGKV1-13

Across TCGA pan-cancer cohorts, IGKV1-13 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV1-13 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGKV1-13 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1-13 expression acts as an unfavorable survival marker.

SKCM and LIHC are the cancer types where IGKV1-13 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.603	0.876	<.001	23	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV1-13–SKCM (OS)

Open the SKCM breakdown →