Across TCGA patient cohorts, IGKJ5 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKJ5-associated genes across cancer lineages are VDAC2P4, STX18-IT1, and MTND6P2. Each is linked with IGKJ5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKJ5-to-partner and partner-to-IGKJ5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKJ5→partner) and Y-score (partner→IGKJ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VDAC2P4 →	+0.104	+4.661	<.001	.004	3	1
SKCM	STX18-IT1 →	+0.179	+4.352	<.001	.007	3	1
SKCM	MTND6P2 →	+0.141	+4.410	<.001	.006	3	1
SKCM	WWC2-AS1 →	+0.192	+4.993	<.001	.002	3	1
SKCM	SNORD116-25 →	+0.703	+5.454	<.001	<.001	3	1
SKCM	RN7SL690P →	+0.165	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

IGKJ5 survival (RNA) · tumor vs normal (RNA) · all IGKJ5 data types