IGHVIII-76-1

Across TCGA pan-cancer cohorts, IGHVIII-76-1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGHVIII-76-1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHVIII-76-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHVIII-76-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRP show a favorable association.

LUAD, KIRP, and MESO are the cancer types where IGHVIII-76-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.697	0.485	.002	49	view →
KIRP	DFS	Median	IV	0.685	0.040	.002	36	view →
MESO	DFS	Tertile	All	0.099	0.487	<.001	27	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
COAD	OS	Tertile	IV	0.850	0.468	.027	12	view →
SARC	DFS	Tertile	All	0.142	0.416	.016	12	view →
BLCA	DFS	Median	III,IV	0.491	0.267	.024	9	view →
STAD	OS	Tertile	IV	0.668	0.287	.048	4	view →
PRAD	DFS	Median	All	0.857	0.910	.042	2	view →
KIRC	DFS	Tertile	II,III,IV	0.423	0.589	.039	1	view →
THYM	OS	Quartile	All	1.000	0.717	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGHVIII-76-1–LUAD (DFS)

Open the LUAD breakdown →