IGHVIII-76-1

Across TCGA pan-cancer cohorts, IGHVIII-76-1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHVIII-76-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IGHVIII-76-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVIII-76-1 is over-expressed in tumor, although a few such as KIRC and STAD show the opposite, repressed pattern.

KIRC, STAD, and COAD are the cancer types where IGHVIII-76-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIII-76-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.112	.009	4	view →
STAD	Male	III,IV	−0.390	.037	2	view →
COAD	All	IV	−0.377	.009	2	view →
KIRP	All	All	−0.235	.003	2	view →
LUAD	All	All	+0.155	.009	1	view →
LUSC	Female	All	−0.096	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHVIII-76-1–KIRC

Open the KIRC breakdown →