IGHVIII-67-3

Across TCGA patient cohorts, IGHVIII-67-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,149 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHVIII-67-3-associated GO terms across cancer lineages are Antigen receptor-mediated signaling pathway, B cell proliferation, and Cellular response to type II interferon. Each is linked with IGHVIII-67-3 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHVIII-67-3-to-partner and partner-to-IGHVIII-67-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen receptor-mediated signaling pathway grouped by IGHVIII-67-3-low versus IGHVIII-67-3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-67-3→partner) and Y-score (partner→IGHVIII-67-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Antigen receptor-mediated signaling pathway →	+0.102	+0.056	<.001	<.001	3	8
STAD	B cell proliferation →	+0.082	+0.054	<.001	<.001	3	7
STAD	Cellular response to type II interferon →	+0.105	+0.053	<.001	<.001	3	7
STAD	Response to alcohol →	+0.075	+0.051	<.001	<.001	3	6
STAD	Response to protozoan →	+0.088	+0.059	<.001	<.001	3	6
LUSC	B cell mediated immunity →	+0.121	+0.028	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,149 associations by consensus.

Antigen receptor-mediated signaling pathway by IGHVIII-67-3 expression — STAD

Explore this box plot interactively →