IGHVIII-67-3

Across TCGA pan-cancer cohorts, IGHVIII-67-3 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGHVIII-67-3 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher IGHVIII-67-3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVIII-67-3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

DLBC, CESC, and LAML are the cancer types where IGHVIII-67-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.109	0.755	<.001	87	view →
CESC	OS	Tertile	II,III,IV	0.156	0.759	.007	72	view →
LAML	DFS	Tertile	All	0.152	0.586	<.001	36	view →
KIRC	DFS	Tertile	IV	0.106	0.650	<.001	36	view →
THYM	DFS	Tertile	All	0.399	0.897	<.001	36	view →
STAD	OS	Tertile	III,IV	0.170	0.649	.001	21	view →
LUSC	DFS	Tertile	II,III,IV	0.158	0.673	.008	21	view →
HNSC	OS	Tertile	IV	0.238	0.647	.027	9	view →
LUAD	OS	Tertile	All	0.894	0.674	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGHVIII-67-3–DLBC (OS)

Open the DLBC breakdown →