IGHVIII-67-2

Across TCGA pan-cancer cohorts, IGHVIII-67-2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHVIII-67-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHVIII-67-2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHVIII-67-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, KIRP, and MESO are the cancer types where IGHVIII-67-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.829	0.650	<.001	128	view →
KIRP	DFS	Tertile	III,IV	0.168	0.623	.001	72	view →
MESO	OS	Tertile	All	0.808	0.203	.004	54	view →
DLBC	DFS	Tertile	II,III,IV	0.124	0.884	<.001	39	view →
UCEC	OS	Tertile	IV	0.225	0.772	<.001	36	view →
SKCM	DFS	Tertile	All	0.416	0.179	.002	33	view →
BRCA	OS	Tertile	II,III,IV	0.598	0.537	.018	27	view →
CHOL	DFS	Tertile	All	1.000	0.289	.035	18	view →
LIHC	DFS	Tertile	II,III,IV	0.718	0.190	.014	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
LUAD	OS	Tertile	III,IV	0.330	0.611	.008	13	view →
PRAD	OS	Tertile	All	0.937	0.993	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHVIII-67-2–HNSC (DFS)

Open the HNSC breakdown →