IGHVIII-67-2

Across TCGA pan-cancer cohorts, IGHVIII-67-2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHVIII-67-2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHVIII-67-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVIII-67-2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and BRCA are the cancer types where IGHVIII-67-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIII-67-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.314	<.001	10	view →
READ	Male	All	−2.543	.002	6	view →
BRCA	Female	II,III,IV	−0.361	<.001	6	view →
LUAD	All	All	+0.674	<.001	5	view →
PAAD	Female	All	−1.080	.004	2	view →
KIRC	All	All	+0.194	.017	2	view →
ESCA	Male	All	+0.604	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHVIII-67-2–COAD

Open the COAD breakdown →