IGHVIII-5-2

Across TCGA patient cohorts, IGHVIII-5-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,450 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHVIII-5-2-associated GO terms across cancer lineages are Negative regulation of T cell apoptotic process, B cell mediated immunity, and Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation. Each is linked with IGHVIII-5-2 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHVIII-5-2-to-partner and partner-to-IGHVIII-5-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of T cell apoptotic process grouped by IGHVIII-5-2-low versus IGHVIII-5-2-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-5-2→partner) and Y-score (partner→IGHVIII-5-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Negative regulation of T cell apoptotic process →	+0.103	+0.024	<.001	<.001	3	7
THCA	B cell mediated immunity →	+0.090	+0.081	<.001	.001	3	7
PAAD	Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation →	+0.070	+0.038	.008	.001	2	7
KIRC	Negative regulation of leukocyte apoptotic process →	+0.109	+0.015	<.001	.001	3	6
KIRC	Negative regulation of CD4-positive, alpha-beta T cell activation →	+0.070	+0.017	<.001	.001	3	6
KIRC	Antigen receptor-mediated signaling pathway →	+0.074	+0.012	<.001	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,450 associations by consensus.

Negative regulation of T cell apoptotic process by IGHVIII-5-2 expression — KIRC

Explore this box plot interactively →