IGHVIII-5-2

Across TCGA pan-cancer cohorts, IGHVIII-5-2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGHVIII-5-2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher IGHVIII-5-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-5-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

THCA, KIRC, and LIHC are the cancer types where IGHVIII-5-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	III,IV	0.138	0.748	<.001	63	view →
KIRC	DFS	Tertile	All	0.256	0.800	<.001	54	view →
LIHC	DFS	Tertile	All	0.094	0.530	.001	36	view →
GBM	OS	Tertile	All	0.079	0.415	.003	27	view →
HNSC	OS	Tertile	All	0.839	0.667	.022	24	view →
STAD	OS	Tertile	III,IV	0.261	0.647	.016	18	view →
UCEC	OS	Tertile	All	0.718	0.927	.021	18	view →
READ	OS	Tertile	II,III,IV	0.542	0.918	.017	9	view →
LUSC	DFS	Tertile	II,III,IV	0.401	0.613	.029	9	view →
CESC	OS	Tertile	All	0.254	0.599	.046	6	view →
PRAD	DFS	Tertile	All	0.824	0.936	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGHVIII-5-2–THCA (DFS)

Open the THCA breakdown →