IGHVIII-47-1

Across TCGA patient cohorts, IGHVIII-47-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,974 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHVIII-47-1-associated GO terms across cancer lineages are B cell receptor signaling pathway, B cell mediated immunity, and Antigen receptor-mediated signaling pathway. Each is linked with IGHVIII-47-1 in more than 20 cancer types. Because this analysis shows association rather than direction, both IGHVIII-47-1-to-partner and partner-to-IGHVIII-47-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHVIII-47-1-low versus IGHVIII-47-1-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-47-1→partner) and Y-score (partner→IGHVIII-47-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell receptor signaling pathway →	+0.081	+0.085	<.001	<.001	3	21
THCA	B cell mediated immunity →	+0.124	+0.093	<.001	<.001	3	20
ESCA	Antigen receptor-mediated signaling pathway →	+0.065	+0.116	<.001	<.001	3	20
KIRP	Immunoglobulin production →	+0.101	+0.047	<.001	<.001	3	19
ESCA	B cell activation →	+0.061	+0.118	<.001	<.001	2	20
THCA	B cell proliferation →	+0.062	+0.088	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,974 associations by consensus.

B cell receptor signaling pathway by IGHVIII-47-1 expression — THCA

Explore this box plot interactively →