IGHVIII-47-1

Across TCGA pan-cancer cohorts, IGHVIII-47-1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGHVIII-47-1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGHVIII-47-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-47-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

UCS, HNSC, and LUSC are the cancer types where IGHVIII-47-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	IV	0.132	0.718	.002	108	view →
HNSC	DFS	Tertile	All	0.798	0.671	.003	108	view →
LUSC	DFS	Tertile	II,III,IV	0.503	0.656	.006	31	view →
LGG	DFS	Tertile	All	0.304	0.740	.007	24	view →
PAAD	DFS	Tertile	II,III,IV	0.652	0.392	.026	18	view →
BLCA	OS	Tertile	III,IV	0.717	0.521	.040	6	view →
TGCT	DFS	Tertile	All	0.814	0.600	.040	4	view →
COAD	DFS	Tertile	All	0.840	0.673	.046	3	view →
LUAD	DFS	Quartile	All	0.779	0.651	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGHVIII-47-1–UCS (DFS)

Open the UCS breakdown →